Publications

2025

Sergey V. Pirozhkov, Marina N. Vukolova, Varvara V. Bulgakova, Yulia A. Lutokhina, Sergey B. Bolevich, Alexander I. Sobolevsky and Maria V. Yelshanskaya «Endothelium glutamate receptors in brain pathology», Frontiers in Pharmacology, 2025, vol 16:
Tania Valencia, Laura Y. Yen, Cindy Berman, Thomas Vincent, Scott Davis, Francesca Varrone, Jianfeng Huang, Jessica Mastroianni, Morgan Carlson, Tate Owen, Amin Kamel, Denis Drygin, Garth A. Kinberger, Shanti Pal Gangwar, Maria V. Yelshanskaya, John Ridley, Robert Kirby, Jesus Alvarez, Ronak Lakhia, Vishal Patel, Alexander I. Sobolevsky & Edmund C. Lee «The nucleobase guanine at the 3’-terminus ofoligonucleotide RGLS4326 drives off-targetAMPAR inhibition and CNS toxicity», Nature Communications, 2025, 16, Article number: 10762 (2025)
Arthus Neuberger, Alexey Shalygin, Irina Veretenenko, Yuri A. Trofimov, Thomas Gudermann, Vladimir Chubanov, Roman G. Efremov, Alexander I. Sobolevsky «The locking mechanism of human TRPV6 inhibition by intracellular magnesium», Nature Communacations, 2025,
Shanti P. Gangwar, Maria V. Yelshanskaya, Laura Y. Yen, Thomas P. Newton and Alexander I. Sobolevsky «Structure and gating of kainate receptors», Frontiers in Pharmacology, 2025, 16:1662316
Shanti Pal Gangwar, Maria V. Yelshanskaya, Laura Y. Yen, Thomas P. Newton & Alexander I. Sobolevsky «Activation of kainate receptor GluK2–Neto2 complex», Nature Structural and Molecular Biology, 2025, 22 August 2025
R. Sánchez-Hernández, M. Benítez-Angeles, I.A. Talyzina, I. Llorente, M. González-Avendaño, F. Sierra, A. Méndez-Reséndiz, F. Mercado, A. Vergara-Jaque, A.I. Sobolevsky, L.D. Islas, & T. Rosenbaum «Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes», Proc. Natl. Acad. Sci. U.S.A., 2025, 122 (29) :e2506560122
Irina A. Talyzina, Kirill D. Nadezhdin, Alexander I. Sobolevsky «Forty sites of TRP channel regulation», Current Opinion in Chemical Biology, 2025, Volume 84, February 2025, 102550
Arthur Neuberger, Alexey Shalygin, Yury A. Trofimov, Irina I. Veretenenko, Kirill D. Nadezhdin, Nikolay A. Krylov, Thomas Gudermann, Roman G. Efremov, Vladimir Chubanov, Alexander I. Sobolevsky «Structure-function analyses of human TRPV6 ancestral and derived haplotypes», Structure, 2025, Volume 33, Issue 1, 91 - 103 .e5

2024

Shanti P. Gangwar, Maria V. Yelshanskaya, Muhammed Aktolun, Laura Y. Yen, Thomas P. Newton, Kristian Stromgaard, Maria G. Kurnikova, Alexander I. Sobolevsky «Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels», Nature Communications, 2024, 15: Article number: 10257
Kirill D. Nadezhdin, Alexander I. Sobolevsky «Thermo-TRPs: Temperature-sensitive TRP channels», TRP Channels as Therapeutic Targets, 2024, Pages 53-70
Yury A. Trofimov, Nikolay A. Krylov, Alexander S. Minakov, Kirill D. Nadezhdin, Arthur Neuberger, Alexander I. Sobolevsky, Roman G. Efremov «Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels», Communications Chemistry, 2024, 7, 119
Shanti Pal Gangwar, Maria V. Yelshanskaya, Kirill D. Nadezhdin, Laura Y. Yen, Thomas P. Newton, Muhammed Aktolun, Maria G. Kurnikova & Alexander I. Sobolevsky «Kainate receptor channel opening and gating mechanism — role of lectin Concanavalin A», Nature, 2024, 1-24
Kirill D. Nadezhdin, Arthur Neuberger, Lena S. Khosrof, Irina A. Talyzina, Jeffrey Khau, Maria V. Yelshanskaya and Alexander I. Sobolevsky «TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site», Sceince Advances, 2024, Vol 10, Issue 18
Kirill D. Nadezhdin, Leonor Correia, Alexey Shalygin, Muhammed Aktolun, Arthur Neuberger, Thomas Gudermann, Maria G. Kurnikova, Vladimir Chubanov and Alexander I. Sobolevsky «Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930», Cell Reports, 2024, vol. 43, is. 4: #114108
Priya R. Banerjee, Alex S. Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I. Sobolevsky, Jennifer M. Hurley, Joshua T. Mendell «Dissecting the biophysics and biology of intrinsically disordered proteins», Trends in Biochemical Sciences, 2024, Volume 49, Issue 2, February 2024, Pages 101-104

2023

Marina N. Vukolova, Laura Y. Yen, Margarita I. Khmyz, Alexander I. Sobolevsky and Maria V. Yelshanskaya «Parkinson’s disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors», Frontiers in Cell and Developmental Biology, 2023, Volume 11
Arthur Neuberger and Alexander I Sobolevsky «Molecular pharmacology of the onco-TRP channel TRPV6», Channels (Austin), 2023, Dec 17(1):2266669
Arthur Neuberger and Alexander I. Sobolevsky «Pentameric TRPV3: an artifact or a clue to channel function?», Cell Calcium, 2023, online 29 September 2023, 102812
Shanti Pal Gangwar, Laura Y. Yen, Maria V. Yelshanskaya, Aryeh Korman, Drew R. Jones and Alexander I. Sobolevsky «Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2», Nature Structural & Molecular Biology, 2023, 1-30
Arthur Neuberger, Yury A. Trofimov, Maria V. Yelshanskaya, Jeffrey Khau, Kirill D. Nadezhdin, Lena S. Khosrof, Nikolay A. Krylov, Roman G. Efremov & Alexander I. Sobolevsky «Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin», Nature Communications, 2023, 14, Article number: 4630
Kirill D. Nadezhdin, Irina A. Talyzina, Aravind Parthasarathy, Arthur Neuberger, David X. Zhang & Alexander I. Sobolevsky «Structure of human TRPV4 in complex with GTPase RhoA», Nature Communication, 2023, open access
Arthur Neuberger, Yury A. Trofimov, Maria V. Yelshanskaya, Kirill D. Nadezhdin, Nikolay A. Krylov, Roman G. Efremov & Alexander I. Sobolevsky «Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein», Nature Communications, 2023, 14: #2659
Kirill D. Nadezhdin, Leonor Correia, Chamali Narangoda, Dhilon S. Patel, Arthur Neuberger, Thomas Gudermann, Maria G. Kurnikova, Vladimir Chubanov and Alexander I. Sobolevsky «Structural mechanisms of TRPM7 activation and inhibition», Nature Communications, 2023, 14, Article number: 2639
Arthur Neuberger, Mai Oda, Yury A. Nikolaev, Kirill D. Nadezhdin, Elena O. Gracheva, Sviatoslav N. Bagriantsev and Alexander I. Sobolevsky «Human TRPV1 structure and inhibition by the analgesic SB-366791», Nature Communications, 2023, 14, #2451
Shanti Pal Gangwar, Laura Y. Yen, Maria V. Yelshanskaya and Alexander I. Sobolevsky «Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel», Cell reports, 2023, 1-17

2022

M. V. Yelshanskaya and A. I. Sobolevsky «Structural Insights into Function of Ionotropic Glutamate Receptors», Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2022, Vol. 16, No. 3, pp. 190–206
Kirill D. Nadezhdin, Arthur Neuberger, Alexander I. Sobolevsky «Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists», Cell Calcium, 2022, vol 105: 102607
Arthur Neuberger, Kirill D. Nadezhdin & Alexander I. Sobolevsky «Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine», Nature Communications, 2022,
Maria V. Yelshanskaya and Alexander I. Sobolevsky «Ligand-Binding Sites in Vanilloid-Subtype TRP Channels», Frontiers in Pharmacology, 2022, 16 May
Maria V. Yelshanskaya, Dhilon S. Patel, Christopher M. Kottke, Maria G. Kurnikova and Alexander I. Sobolevsky «Opening of glutamate receptor channel to subconductance levels», Nature, 2022,
Maria V. Yelshanskaya, Appu K. Singh, Chamali Narangoda, Robin S.B. Williams, Maria G. Kurnikova, Alexander I. Sobolevsky «Structural basis of AMPA receptor inhibition by 4-BCCA», British Journal of Pharmacology , 2022, p. 3628-3644

2021

Kasper B. Hansen, Lonnie P. Wollmuth, Derek Bowie, Hiro Furukawa, Frank S. Menniti, Alexander I. Sobolevsky, Geoffrey T. Swanson, Sharon A. Swanger, Ingo H. Greger, Terunaga Nakagawa, Chris J. McBain, Vasanthi Jayaraman, Chian-Ming Low, Mark L. Dell’Acqua, Jeffrey S. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan and Stephen F. Traynelis «Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels», Pharmacological Reviews, 2021, 73 (4): 298-487
Arthur Neuberger, Kirill D. Nadezhdin and Alexander I. Sobolevsky «Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole», Nature Communications, 2021, 12: 6284
Oleg Klykov, Shanti Pal Gangwar, Maria V. Yelshanskaya, Laura Yen and Alexander I. Sobolevsky «Structure and desensitization of AMPA receptor complexes with type II TARP gamma5 and GSG1L», Molecular Cell, 2021, 81: 1-13
Ramsey Bekdash, Jose R. Quejada, Shunnosuke Ueno, Fuun Kawano, Kumi Morikawa, Alison D. Klein, Kenji Matsumoto, Tetz C. Lee, Koki Nakanishi, Amy Chalan, Teresa M. Lee, Rui Liu, Shunichi Homma, Chyuan-Sheng Lin, Maria V. Yelshanskaya, Alexander I. Sobolevsky, Keisuke Goda, Masayuki Yazawa «GEM-IL: A highly responsive fluorescent lactate indicator», Cell Reports Methods, 2021, Oct 21: pp. 1-19
Shanti Pal Gangwar, Marriah N. Green, Maria V. Yelshanskaya and Alexander I. Sobolevsky «Purification and cryo-EM structure determination of Arabidopsis thaliana GLR3.4», STAR Protocol, 2021, Sep. 30: 1-17
Arthur Neuberger, Kirill D. Nadezhdin, Eleonora Zakharian, Alexander I. Sobolevsky «Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole», EMBO Reports, 2021, e53233
Kirill D. Nadezhdin, Arthur Neuberger, Yuri A. Trofimov, Nikolay A. Krylov, Viktor Sinica, Nikita Kupko, Viktorie Vlachova, Eleonora Zakharian, Roman G. Efremov & Alexander I. Sobolevsky «Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel», Nature Structural & Molecular Biology, 2021, 28 (7): 564-572
Marriah N. Green, Shanti Pal Gangwar, Erwan Michard, Alexander A. Simon, Maria Teresa Portes, Juan Barbosa-Caro, Michael M. Wudick, Michael A. Lizzio, Oleg Klykov, Maria V. Yelshanskaya, José A. Feijó, Alexander I. Sobolevsky «Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4», Molecular Cell, 2021, v. 81, Issue 15: 3216-3226
Kirill D. Nadezhdin, Arthur Neuberger, Yury A. Nikolaev, Lyle A. Murphy, Elena O. Gracheva, Sviatoslav N. Bagriantsev & Alexander I. Sobolevsky «Extracellular cap domain is an essential component of the TRPV1 gating mechanism», Nature Communications, 2021, 12: 2154
Arthur Neuberger, Kirill D. Nadezhdin, Alexander I. Sobolevsky «TRPV3 expression and purification for structure determination by Cryo-EM», Methods in Enzymology, 2021, 652: 31-48
Shanti Pal Gangwar, Marriah N. Green, Erwan Michard, Alexander A. Simon, José A. Feijó, Alexander I. Sobolevsky «Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain», Structure, 2021, Volume 29, Issue 2: 161-169
Yelshanskaya MV, Nadezhdin KD, Kurnikova MG, Sobolevsky AI. «Structure and function of the calcium-selective TRP channel TRPV6», J. Physiology, 2021, Vol 599, Issue 10: 2673-2697

2020

Rajesh Bhardwaj, Sonja Lindinger, Arthur Neuberger, Kirill D. Nadezhdin, Appu K. Singh, Micael R. Cunha, Isabella Derler, Gergely Gyimesi, Jean-Louis Reymond, Matthias A. Hediger, Christoph Romanin, Alexander I. Sobolevsky «Inactivation-mimicking block of the epithelial calcium channel TRPV6», Science Advances, 2020, Vol. 6, no. 48
Riley E Perszyk, Scott J Myers, Hongjie Yuan, Alasdair J Gibb, Hiro Furukawa, Alexander I Sobolevsky, Stephen F Traynelis «Hodgkin-Huxley-Katz Prize Lecture: Genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif», Journal of Physiology, 2020, 598(15): 3071–3083

2019

Shanti Pal Gangwar, Marriah Green and Alexander I. Sobolevsky «Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain», BioRxiv, 2019, (Dec 24): 1-22
Appu K. Singh, Luke L. McGoldrick, Lusine Demirkhanyan, Merfilius Leslie, Eleonora Zakharian and Alexander I. Sobolevsky «Structural basis of temperature sensation by the TRP channel TRPV3», Nature Structural & Molecular Biology, 2019, 26: 994–998
Edward C. Twomey, Maria V. Yelshanskaya, Alexander I. Sobolevsky «Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes», Journal of General Physiology, 2019, 1540-7748
Luke L. McGoldrick, Appu K. Singh, Lusine Demirkhanyan, Ting-Yu Lin, Ryan G. Casner, Eleonora Zakharian, Alexander I. Sobolevsky «Structure of the Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas Reinhardtii», Nature Communications, 2019, Sept 13; 10(1):4180.
Lucie Macikova, Lenka Vyklicka, Ivan Barvik, Alexander I. Sobolevsky, Viktorie Vlachova «Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel», International Journal of Molecular Science, 2019, 20(16), 3990
Appu K. Singh, Luke L. McGoldrick, Alexander I. Sobolevsky «Expression, Purification, and Crystallization of the Transient Receptor Potential Channel TRPV6», Methods in Molecular Biology , 2019, volume 1987: pp 23-37

2018

Alexander I. Sobolevsky «Influences: Russian training», Journal of General Physiology, 2018, 150: 1596-1598
Appu K. Singh*, Luke L. McGoldrick*, Alexander I. Sobolevsky «Structure and gating mechanism of the transient receptor potential channel TRPV3», Nature Structural & Molecular Biology, 2018, 25: 805-813
Edward C. Twomey, Maria V. Yelshanskaya, Alexander A. Vassilevski, Alexander I. Sobolevsky «Mechanisms of channel block in calcium-permeable AMPA receptors», Neuron, 2018, 99: 956-968
Appu K.Singh*, Luke McGodrick*, Edward C. Twomey, Alexander I. Sobolevsky «Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6», Science Advances, 2018, 4 (8): eaau6088
Appu K. Singh*, Kei Saotome*, Luke L. McGoldrick, Alexander I. Sobolevsky «Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB», Nature Communications, 2018, 9: 2465
Appu K. Singh, Luke L. McGoldrick, Kei Saotome, Alexander I. Sobolevsky «X-ray crystallography of TRP channels», Channels, 2018, 12: 137-152
Serzhan Sakipov, Alexander I. Sobolevsky, Maria G. Kurnikova «Ion permeation mechanism in epithelial calcium channel TRVP6», Scientific Reports, 2018, 8: 5715
Dmitry I. Osmakov, Sergey G. Koshelev, Yaroslav A. Andreev, Maxim A. Dubinnyi, Vadim S. Kublitski, Roman G. Efremov, Alexander I. Sobolevsky, Sergey A. Kozlov «Proton-independent activation of acid-sensing ion channel 3 by an alkaloid, lindoldhamine, from Laurus nobilis», British Journal of Pharmacology, 2018, 175 (6): 924-937
Luke L. McGoldrick*, Appu K. Singh*, Kei Saotome, Maria V. Yelshanskaya, Edward C. Twomey, Robert A. Grassucci, Alexander I. Sobolevsky «Opening of the human epithelial calcium channel TRPV6», Nature, 2018, 553: 233-237
Edward C. Twomey, Alexander I. Sobolevsky «Structural mechanisms of gating in ionotropic glutamate receptors», Biochemistry, 2018, 57 (3): 267-276
Appu K. Singh, Kei Saotome, Alexander I. Sobolevsky «Determining the crystal structure of TRPV6», Calcium Entry Channels in Non-Excitable Cells, 2018, ISBN 978-1-4987-5272-5

2017

Appu K. Singh, Kei Saotome, Alexander I. Sobolevsky «Swapping of transmembrane domains in the epithelial calcium channel TRPV6», Scientific Reports, 2017, 7: 10669
Edward C. Twomey, Maria V. Yelshanskaya, Robert A. Grassucci, Joachim Frank, Alexander I. Sobolevsky «Channel opening and gating mechanism in AMPA-subtype glutamate receptors», Nature, 2017, 549: 60-65
Edward C. Twomey, Maria V. Yelshanskaya, Robert A. Grassucci, Joachim Frank, Alexander I. Sobolevsky «Structural bases of desensitization in AMPA receptor-auxiliary subunit complexes», Neuron, 2017, 94 (3): 569-580.E5
Maria V. Yelshanskaya, Samaneh Mesbahi-Vasey, Maria G. Kurnikova, Alexander I. Sobolevsky «Role of the ion channel extracellular collar in AMPA receptor gating», Scientific Reports, 2017, 7: 1050

2016

Maria V. Yelshanskaya, Appu K. Singh, Jared M. Sampson, Chamali Narangoda, Maria Kurnikova, Alexander I. Sobolevsky «Structural bases of noncompetitive inhibition of AMPA-subtype ionotropic glutamate receptors by antiepileptic drugs», Neuron, 2016, 91 (6): 1305-1315
Edward C. Twomey, Maria V. Yelshanskaya, Robert A. Grassucci, Joachim Frank, Alexander I. Sobolevsky «Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy», Science, 2016, 353 (6294): 83-86
Kei Saotome, Appu K. Singh, Maria V. Yelshanskaya, Alexander I. Sobolevsky «Crystal structure of the epithelial calcium channel TRPV6», Nature, 2016, 534: 506-511
Maria V. Yelshanskaya, Kei Saotome, Appu K. Singh, Alexander I. Sobolevsky «Probing intersubunit interfaces in AMPA-subtype ionotropic glutamate receptors», Scientific Reports, 2016, 6: 19082
Maria V. Yelshanskaya, Kei Saotome, Minfen Li, Alexander I. Sobolevsky «Expression, purification, and crystallization of full length ionotropic glutamate receptors», Neuromethods, 2016, IGRT: 83-100

2015

Alexander I. Sobolevsky «Structure and gating of tetrameric glutamate receptors», The Journal of Physiology, 2015, 593.1: 29-38

2014

Maria V. Yelshanskaya, Minfen Li, Alexander I. Sobolevsky «Structure of an agonist-bound ionotropic glutamate receptor», Science, 2014, 345: 1070-1074

2013 — earlier

Alexander I. Sobolevsky, Michael P. Rosconi, Eric Gouaux «X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor», Nature, 2009, 462 (7274): 745-56
Rongsheng Jin, Satinder K. Singh, Shenyan Gu, Hiroyasu Furukawa, Alexander I. Sobolevsky, Jie Zhou, Yan Jin, Eric Gouaux «Crystal structure and association behaviour of the GluR2 amino-terminal domain», The EMBO Journal, 2009, 28: 1812-1823
Alexander I. Sobolevsky, Michael L. Prodromou, Maria V. Yelshansky, Lonnie P. Wollmuth «Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating», Journal of General Physiology, 2007, 129 (6): 509-525
Maria V. Yelshansky, Alexander I. Sobolevsky, Claudia Jatzke, Lonnie P. Wollmuth «Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain», Journal of Neuroscience, 2004, 24 (20): 4728-4736
Alexander I. Sobolevsky, Maria V. Yelshansky, Lonnie P. Wollmuth «The outer pore of the glutamate receptor channel has two-fold rotational symmetry», Neuron, 2004, 41 (3): 367-378
Alexander I. Sobolevsky, Maria V. Yelshansky, Lonnie P. Wollmuth «Different gating mechanisms in glutamate receptor and K⁺ channels», Journal of Neuroscience, 2003, 23 (20): 7559-7568
Alexander I. Sobolevsky, LeeAnn Rooney, Lonnie P. Wollmuth «Staggering of subunits in NMDAR channels», Biophysical Journal, 2002, 83 (6): 3304-3314
Alexander I. Sobolevsky, Beck C., Lonnie P. Wollmuth «Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating», Neuron, 2002, 33 (1): 75-85