Swapping of transmembrane domains in the epithelial calcium channel TRPV6
Published on 09.06.2017 in Scientific Reports
Appu K. Singh, Kei Saotome, Alexander I. Sobolevsky
Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.