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Scientific Reports

Swapping of transmembrane domains in the epithelial calcium channel TRPV6

Published on 09.06.2017 in Scientific Reports

Authors: Appu K. Singh, Kei SaotomeAlexander I. Sobolevsky

Abstract

Tetrameric ion channels have either swapped or non-swapped arrangements of the S1–S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

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