Dissecting the biophysics and biology of intrinsically disordered proteins
Published on 11.09.2023 in Trends in Biochemical Sciences
Priya R. Banerjee, Alex S. Holehouse, Richard Kriwacki, Paul Robustelli, Hao Jiang, Alexander I. Sobolevsky, Jennifer M. Hurley, Joshua T. Mendell
Intrinsically disordered regions (IDRs) within human proteins play critical roles in cellular information processing, including signaling, transcription, stress response, DNA repair, genome organization, and RNA processing. Here, we summarize current challenges in the field and propose cutting-edge approaches to address them in physiology and disease processes, with a focus on cancer.