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Crystallography in the 21st century. Reflections on Raj Rajashankar

Published on 11.14.2019

The symposium on crystallography in the 21st century was dedicated to Dr. Kanagalaghatta (Raj) Rajashankar, who was the longtime Associate Director of the Northeastern Collaborative Access Team at the Advanced Photon Source of Argonne National Laboratory.


For the first time, temperature-induced ion channel opening is captured structurally!

Published on 10.21.2019

Transient receptor potential (TRP) channels sense temperature in organisms ranging from yeast to human but the molecular mechanisms of thermosensation have been an enigma. In our new paper published in NSMB we present structures of the TRP channel TRPV3, which is predominantly expressed in skin keratinocytes, is implicated in thermo-sensation, nociception, itch, maintenance of the skin barrier, wound healing and hair growth, and is associated with numerous human skin diseases, including a genodermatosis known as Olmsted syndrome, atopic dermatitis, psoriasis and rosacea.


Columbia’s new Cryo-Electron Microscopy Center

Published on 09.19.2019

Columbia University has opened a state-of-the-art center for cryo-EM facility in September 2019. Inside are the most advanced tools in the world for studying biology at the molecular scale. Nobel Laureate Professor Joachim Frank with Columbia officials opened the facility.


Structure of the Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas Reinhardtii

Published on 09.16.2019

Our structures of a new, uniquely folded, 2-fold symmetrical and highly temperature-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii that opens in response to increased temperature and is positively regulated by the membrane lipid PIP2 (phosphatidylinositol-4,5-bisphosphate) have been published in Nature Communications.


New PhD — Dr. Luke McGoldrick

Published on 08.21.2019

Luke McGoldrick joined our lab in 2016 as a Integrated Program Graduate student. During his PhD training he was part of the ongoing research in TRP channels structure-function.


RICCEM 2019

Published on 08.20.2019

Dr. Sobolevsky was an invited speaker at the Russian International Conference on Cryo-EM, Moscow, Russia, June 2-5, 2019. The title of the talk was «Structural and functional studies of vanilloid subtype TRP channels».


AMPA Receptor is the Molecule of the Month

Published on 07.15.2019

AMPA receptor, with an inhibitor (red) bound to the glutamate-binding domains. The location of the cell membrane is shown schematically in gray. Nerve cells in our brain communicate with one another using small neurotransmitter molecules. These come in many shapes and sizes, such as acetylcholine, serotonin and endorphins, allowing the nervous system to shape the way neurons talk to one another. The amino acid glutamate is one of the most common neurotransmitters used to carry excitatory signals.


Dr. Sobolevsky visited 49th NIPS International Symposium

Published on 12.12.2018

NIPS symposium

The 49th NIPS international Symposium «ION CHANNELS: LOOKING BACK, SEEING AHEAD» was held at Okazaki, Japan in December 2018. As we are experiencing amazingly progressing world of bioscience, we can now obtain new information of molecular structure, protein-protein interaction, genetic regulation, biological functions and other aspects of ion channels.


iGluR retreat 2018, Pittsburgh, PA

Published on 08.07.2018

Dr. Sobolevsky at iGluR retreat 2018

This year iGluR retreat was held at University of Pittsburgh, July 31 – August 2. Dr. Alexander Sobolevsky presented the poster titled «Mechanisms of channel block in Calcium-Permeable AMPA receptors». This work was published in Neuron on August 16, 2018.


CMBS Integrated Program Retreat 2018

Published on 07.25.2018

Sobolevsky Lab at CMBS Integrated Program Retreat 2018

Luke presented his work on TRPV6 channel opening mechanism at Cellular, Molecular and Biomedical Sciences (CMBS) Columbia University Graduate Program Retreat 2018, Glen Cove Mansion, Glen Cove, NY.


2018 Ion Channels Gordon Research Conference

Published on 07.19.2018

GRC Ion Channels group photo

Dr. Alexander Sobolevsky presented a talk «Structural Mechanisms of Gating in Ionotropic Glutamate Receptors» at 2018 Ion Channels Gordon Research Conference at Mt. Holoyoke College, South Hadley, MA.


iGluR retreats

Published on 05.17.2018

iGluR retreat Pittsburgh PA 2018

The first ionotropic glutamate receptor retreat (iGluRetreat) was organized by Dr. Gabriela Popescu (University of Buffalo, NY) and Dr. Derek Bowie (McGill University, Montreal, Canada) and was held at Cornell University in Ithaca, NY in 2013.


DEAN’s award

Published on 05.15.2018

DEAN’s award

To be named DEAN’s award recipient is a tremendous accomplishment! Congratulations, Ed! Hooding ceremony, Columbia University Medical Center, May 13, 2018.


Ed Twomey on PhD

Published on 04.05.2018

Congratulations to Ed Twomey on PhD!

Here is the poster of the today’s PhD defense of Ed Twomey.