Published on 11.08.2019
This study by Yelshanskaya et al. provides evidence showing that the combination of the agonist binding and clamshell closure provides the energy to drive channel opening in all ionotropic glutamate receptors. See https://f1000.com/prime/727542732
Published on 10.21.2019
Transient receptor potential (TRP) channels sense temperature in organisms ranging from yeast to human but the molecular mechanisms of thermosensation have been an enigma. In our new paper published in NSMB we present structures of the TRP channel TRPV3, which is predominantly expressed in skin keratinocytes, is implicated in thermo-sensation, nociception, itch, maintenance of the […]
Published on 10.15.2019
This review is published in Journal of General Physiology on October 15, 2019. Here we discuss recent advances into the structure and function of AMPA receptor regulation by TARP auxiliary subunits. Details can be found here.
Published on 09.19.2019
Columbia University has opened a state-of-the-art center for cryo-EM facility. Inside are the most advanced tools in the world for studying biology at the molecular scale. Nobel Laureate Joachim Frank with Columbia official opened facility. Detalis about Cryo-Electron Microscopy Center website.
Published on 09.16.2019
Our structures of a new, uniquely folded, 2-fold symmetrical and highly temperature-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii that opens in response to increased temperature and is positively regulated by the membrane lipid PIP2 (phosphatidylinositol-4,5-bisphosphate) have been published in Nature Communications.
Published on 08.21.2019
Congratulations to our student Luke McGoldrick with successful PhD defense! Luke joined our lab in 2016 as a Integrated Program Graduate student. During his PhD training he was part of the ongoing research in TRP channels structure-function. Lab published several papers with his first and co-first authorship including Nature, Science Advances, Nature Communications, NSMB. Luke […]
Published on 08.20.2019
Dr. Sobolevsky was an invited speaker at the Russian International Conference on Cryo-EM, Moscow, Russia, June 2-5, 2019. The title of the talk was «Structural and functional studies of vanilloid subtype TRP channels». Leading researchers from Russia, Europe and the USA took part in this conference. Recent advances in deciphering the atomic structure of macromolecules […]
Published on 07.15.2019
AMPA Receptor Receptors for the neurotransmitter glutamate in our brain come in several shapes and sizes. AMPA receptor, with an inhibitor (red) bound to the glutamate-binding domains. The location of the cell membrane is shown schematically in gray.Download high quality TIFF imageNerve cells in our brain communicate with one another using small neurotransmitter molecules. These […]
Published on 05.08.2019
Dr. Sobolevsky presented at 2019 International Conference on Neurostructural Biology at Tsinghua University, Beijing, China, April 21-22 2019.
Published on 12.12.2018
The 49th NIPS international Symposium «ION CHANNELS: LOOKING BACK, SEEING AHEAD» was held at Okazaki, Japan in December 2018. As we are experiencing amazingly progressing world of bioscience, we can now obtain new information of molecular structure, protein-protein interaction, genetic regulation, biological functions and other aspects of ion channels.
Published on 12.03.2018
Essay from Dr. Sobolevsky titles «JGP 100th Anniversary: Influences: Russian training» is published in Journal of General Physiology on December 3, 2018.
Published on 09.06.2018
Our paper was featured on the current issue of Nature Structural & Molecular Biology cover! Activating TRPV3. Natural compounds from the camphor tree, oregano, clove and thyme activate the TRPV3 channel. Cryo-EM analyses of mouse TRPV3 provide insights into gating mechanisms.
Published on 09.05.2018
Our paper «Mechanisms of channel block in calcium-permeable AMPA receptors» was featured on the Neuron cover (issue from Sep 5th, 2018).
Published on 08.07.2018
This year iGluR retreat was held at University of Pittsburgh, July 31 – August 2. Dr. Alexander Sobolevsky presented the poster titled «Mechanisms of channel block in Calcium-Permeable AMPA receptors». This work was published in Neuron on August 16, 2018.
Published on 07.25.2018
Luke presented his work on TRPV6 channel opening mechanism at Cellular, Molecular and Biomedical Sciences (CMBS) Columbia University Graduate Program Retreat 2018, Glen Cove Mansion, Glen Cove, NY.
Published on 07.19.2018
Dr. Alexander Sobolevsky presented a talk «Structural Mechanisms of Gating in Ionotropic Glutamate Receptors» at 2018 Ion Channels Gordon Research Conference at Mt. Holoyoke College, South Hadley, MA.
Published on 05.17.2018
The first ionotropic glutamate receptor retreat (iGluRetreat) was organized by Dr. Gabriela Popescu (University of Buffalo, NY) and Dr. Derek Bowie (McGill University, Montreal, Canada) and was held at Cornell University in Ithaca, NY in 2013.
Published on 05.15.2018
To be named DEAN’s award recipient is a tremendous accomplishment! Congratulations, Ed! Hooding ceremony, Columbia University Medical Center, May 13, 2018.
Published on 04.05.2018
Here is the poster of the today’s PhD defense of Ed Twomey.