Thermo-TRPs: Temperature-sensitive TRP channels

Chapter 4 — in TRP channels as Therapeutic Targets Targets (Second Addition Book 2024)

Abstract

In this chapter, we define ion channel thermosensitivity and focus on exploring the temperature sensitive transient receptor potential channels, thermo-TRPs. The discussion revolves around the structures, thermodynamics, and molecular determinants of temperature controlled thermo-TRP gating. We summarize the current understanding of heat- and cold-sensing mechanisms and their significance for organismal physiology and highlight unanswered questions.

About the book

Description

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.

Key Features

• Presents the perspectives of several life science research specialties on the topic
• Provides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practice
• Represents an updated and complete reference

ISBN

978-0-443-18653-0