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Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain

Published on 10.06.2020 in Structure

Authors:

Shanti Pal Gangwar, Marriah N. Green, Erwan Michard, Alexander A. Simon, José A. Feijó, Alexander I. Sobolevsky

Highlights

  • AtGLR3.2 LBD structures were solved in complex with agonists glycine and methionine.
  • AtGLR3.2 LBD structures show clamshell architecture typical for vertebrate iGluRs.
  • Mutation of R133 that is critical for agonist binding increases channel’s activity.
  • Structural conservation between GLRs and iGluRs predicts common gating principles.

This work was done in collaboration with Dr. Feijo group from University of Maryland.

The original work «Structure of the Glutamate-Like Receptor GLR3.2 ligand-binding domain» by Shanti Pal Gangwar, Marriah Green, Alexander I. Sobolevsky was published in BioRxiv on Dec 24, 2019.

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