Welcome to the Sobolevsky Lab!

We study ion channels using an array of structural, biochemical, and biophysical techniques.

Noncompetitive inhibition of AMPARs by epileptic drugs

Here, we show for the first time how epileptic drugs interact with AMPARs to inhibit channel function.

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Cryo-EM reveals structure of AMPA-receptor complexes

We provide the first evidence of how AMPA-receptors assemble with auxiliary transmembrane subunits, and provide insights into the regulation mechanism.

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Crystal structure of TRPV6 reveals calcium uptake mechanism

We show, in atomic detail, a mechanism for ion permeation in calcium-selective ion channels.

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