Welcome to the Sobolevsky Lab!

Based in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center, we study ion channel signaling using cryo-electron microscopy, X-ray crystallography, electrophysiology and biophysical techniques.

Identification of drug binding sites via crystallography

Here, we show for the first time how epileptic drugs interact with AMPARs to inhibit channel function.

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Cryo-EM reveals structures of major brain signaling complexes

We show the first evidence of how AMPARs form complexes with subunits and function in response to the neurotransmitter glutamate.

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Structures of the epithelial calcium channel of TRPV6

Here, using X-ray crystallography, we show in atomic detail a mechanism for ion permeation in calcium-selective ion channels.

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