Welcome to the Sobolevsky Lab!

We study ion channels using an array of structural, biochemical, and biophysical techniques.

Probing interface dynamics in AMPA Receptors

Here, we use cysteine crosslinking to identify how subunit interfaces in AMPA-subtype ionotropic glutamate receptors change upon channel gating.

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Cryo-EM reveals structure of AMPA-receptor complexes

We provide the first evidence of how AMPA-receptors assemble with auxiliary transmembrane subunits, and provide insights into the regulation mechanism.

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Crystal structure of TRPV6 reveals calcium uptake mechanism

We show, in atomic detail, a mechanism for ion permeation in calcium-selective ion channels.

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